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Multiplex approaches in protein microarray technology.

Kersten B, Wanker EE, Hoheisel JD, Angenendt P

Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany. b.kersten@mdc-berlin.de

The success of genome sequencing projects has provided the basis for systematic analysis of protein function and has led to a shift from the description of single molecules to the characterization of complex samples. Such a task would not be possible without the provision of appropriate high-throughput technologies, such as protein microarray technology. In addition, the increasing number of samples necessitates the adaptation of such technologies to a multiplex format. This review will discuss protein microarray technology in the context of multiplex analysis and highlight its current prospects and limitations.

Published 15 August 2005 in Expert Rev Proteomics, 2(4): 499-510.
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