Microarrays Research Today is a free monthly online journal that collates and summarizes the latest research about Microarrays, including details on experiments, designs, statistics, analysis, software.

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals.

Ghazani AA, Lee JA, Klostranec J, Xiang Q, Dacosta RS, Wilson BC, Tsao MS, Chan WC

Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada.

We developed and validated a novel method for quantifying protein expression of cancer tumors in an accurate, sensitive, and high throughput format. This technique integrates quantum dots, tissue microarray, optical spectroscopy, and algorithm design for analysis of tumor biopsies. The integration of this method for tissue analysis in the clinic bears potential impact for improving the diagnosis and treatment of cancer.

Published 13 December 2006 in Nano Lett, 6(12): 2881-6.
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