Microarrays Research Today is a free monthly online journal that collates and summarizes the latest research about Microarrays, including details on experiments, designs, statistics, analysis, software.

Activity-based fingerprinting and inhibitor discovery of cysteine proteases in a microarray.

Uttamchandani M, Liu K, Panicker RC, Yao SQ

Department of Biological Sciences, National University of Singapore, 4 Science Drive 4, 117543, Singapore.

A panel of 20 peptide vinyl sulfone probes has been synthesized and used to generate activity-based fingerprinting profiles of cysteine proteases in both gel- and microarray-based formats; the inhibitor fingerprints of representative small molecule inhibitors targeted against 4 cysteine proteases were also obtained, in high-throughput, using the same protein microarray platform.

Published 4 April 2007 in Chem Commun (Camb).
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